What is the Entourage Effect?

Updated: May 26, 2020

The Entourage Effect is a theory that the various cannabinoids, flavonoids, and terpenes, naturally found in cannabis work together synergistically and when taken together, produce unique effects and benefits on human health.


In short, consuming the entire range of cannabis compounds within hemp benefits your health more than consuming each compound alone. The Entourage Effect helps maximize the therapeutic benefits of full spectrum CBD oil.

Full Spectrum CBD products, like the ones Sustainable CBD offers, provides the Entourage Effect, since it contains all of the natural compounds found in hemp. Due to this, full spectrum CBD products are typically considered to be more beneficial.


Understanding the Chemical Compounds That Contribute to the Entourage Effect

  1. Cannabinoids – There are over 100 cannabinoids, sometimes called phytocannabinoids in cannabis. The most widely known cannabinoids are THC and CBD. Cannabinoids interact with cannabinoid receptors in the Endocannabinoid System (ECS) which result in a better functioning ECS and an overall healthier body.

  2. Terpenes – The aromatic compounds found in all plants. These compounds are responsible for the sweet smell of a fresh pineapple or the floral scent of lavender. Common terpenes are limonene (found in citrus fruits) and linalool (found in lavender). Essential oils are based on terpenes and are known to have therapeutic effects on the human body.

  3. Flavonoids - Like terpenes, flavonoids are found in all types of plants and are responsible for their color. The bright yellow of bananas, fire hydrant reds of tomatoes and deep purples of red onions aren’t the only things flavonoids are responsible for. They also interact with other chemicals in the plant during various growth stages. Research suggests that flavonoids are extremely beneficial for health, as they help support homeostasis, balanced wellness, in the body.

The Entourage Effect

Each compound arrives with unique effects and benefits and their behavior may change in the presence of other compounds, hence the Entourage Effect. When you combine multiple compounds in their natural state, you don’t end up with the sum of each part; instead, you get a multiplying effect, which can amplify each compound’s chemistry, making the overall plant more effective in addressing unwanted symptoms.


Numerous conditions have been studies in conjunction with the Entourage Effect. A study in 2011 (British Journal of Pharmacology) found that taking terpenes and phytocannabinoids together may be beneficial for:

  • Pain

  • Anxiety

  • Inflammation

  • Epilepsy

  • Cancer

  • Fungal infection

The Sustainable CBD Difference


At Sustainable CBD, we believe in the power of the Entourage Effect. All Sustainable CBD products are full spectrum, but there’s one component that makes us different from other CBD companies. Our full spectrum CBD is free of THC, but still contains the beneficial terpenes and flavonoids.


Although the Entourage Effect is still a theory, there is a general consensus in the scientific community that the Entourage Effect is beneficial for providing enhanced benefits associated with hemp. However, more research into the cannabis plant and its chemical composition is needed before we can know the full extent of its positive medical benefits.